It's mostly just a matter of getting something low output enough and bright enough to balance well with the bridge pickup. Ideally you want a slightly hotter, maybe Broadcaster-y kinda bridge pickup, with a low-wind PAF or something more Gretsch-y in the neck.
As far as pro-con it's really just whether you're gonna like the sound -- I had an old LTD TE-202 (IIRC that's the model number, but they changed it a few years back) that had a bridge single and neck humbucker, and aside from the usual issues of a cheaper guitar, I really dug the sounds I got out of it. That was a hotter single with a bit more midrange paired with a lower-output, brighter humbucker (that was also set pretty low from the factory, actually, which helped a lot).